[Imageworld] Post-doc position - Centre de Morphologie Mathématique - FRANCE
meyer at cmm.ensmp.fr
Mon Jan 19 15:28:50 CET 2009
The Centre de Morphologie Mathématique of the ECOLE DES MINES DE PARIS invites applications for a post-doctoral position : automated cellular phenotyping by image processing
Place : Centre de Morphologie Mathématique, Ecole des Mines de Paris (Mines-ParisTech) - 35 rue Saint Honoré - 77300 Fontainebleau - France - website : http://cmm.ensmp.fr/index_eng.html
Contacts: Jesús Angulo, Fernand Meyer
Email: jesus.angulo at ensmp.fr
Tel : +33(0)220.127.116.11.75
Context: The observation of a cell population phenotype, once it has been disturbed, is now a major investigation tool in biology. For instance, blocking a gene with a RNAi may highlight this gene effect over the cell normal functioning. The observation of a toxic molecule may show new action modes and put on the right track to develop new medicines.
As the phenotype modifications are sometimes extremely subtle, it is necessary to develop specific fluorescent markers and to resort to sensitive fluorescence microscopy to observe the phenotypes; in addition, sophisticated image and data processing methods to analyse et quantify the phenotype are to be developed.
The successful candidate for this post-doc position will contribute to develop such methods.
This study is carried out within the framework of a set of other research projects led by the Ecole des Mines together with several academic and industrial partners, with applications in cancer and toxicology research.
Aims: The ideal candidate is self-motivated, holds a PhD, is able to turn theoretical concepts into operational methods and appreciates multidisciplinary studies, closely linked to biology. Indeed, (s)he will develop new methods in order to :
a.. Extract and segment nuclei, cells and sub cellular constituents from the information available in the multiple fluorescent channels associated to the various markers. As cells are objects with very specific shapes, model based segmentation has to be envisaged.
b.. Extract parameters to characterize the size, shape and texture in order to identify the normal and abnormal shapes of the various cell components.
c.. Study the cell distribution in space, in order to characterize the interactions among cells.
d.. Study the motion of living cells, by developing algorithms for tracking them and analysing their deformation.
e.. The tools will be adapted to the different possible cell culture protocoles: cell proliferation, cell differentiation, co-cultures mixing two different cell types.
Skills and knowledge required :
· Good knowledge in image processing, mathematical morphology, and in cell biology. Some experience of data classification and analysis would be an additional advantage
· Good skills in programming in C and C++.
a.. Good knowledge of written and spoken English.
This post-doctorate position is immediately available and the initial appointment is for one year.
Interested candidates should send (preferably as PDFs via e-mail at jesus.angulo at ensmp.fr) a copy of their curriculum vitae including a list of their publications, a summary of their thesis, and recommendation letter(s).
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